Solvent casting-particulate leaching synthesis of a nano-SiO2/chitosan composite scaffold for potential use in bone tissue engineering

This work aimed to introduce nanosized SiO2 into the CS matrix to produce three-dimensional (3D) scaffolds by solvent casting combined with salt leaching using NaCl as a porogen agent. The amount of the porogen to polymer was varied to produce 3D CS/SiO2 scaffolds with suitable pore sizes and porosity.