In vitro depleting antigen - Specific T cells by a promising toxin antibody conjugate

We further confirm the specificity of toxin-conjugated anti-CD137 mAb showing that only T cells that expressed CD137 underwent apoptosis by staining with toxin-FITC-mAb conjugates. We also found that toxinconjugated anti-CD137 mAb was able to delete allore-active T cells in vitro. Our result indicates that CD137 targeted delivery of toxin is a good strategy to delete antigen-specific T cells.