Nghiên cứu chỉ số viêm CRP/albumin và chỉ số sinh xơ vữa ở bệnh nhân nhồi máu cơ tim

Myocardial infarction (MI) represents a critical manifestation of acute coronary syndrome, fundamentally driven by the progression of atherosclerotic plaques within the coronary arteries. Given the significant role of inflammation and dyslipidemia in the pathogenesis and development of these plaques, the utility of inflammatory and atherogenic markers has gained increasing recognition in clinical practice for both screening and prognostic assessment. Specifically, the C-reactive protein to albumin ratio (CAR) has emerged as an independent predictor of major cardiovascular events and coronary artery disease (CAD) severity, while the atherogenic index of plasma (AIP) offers a more comprehensive evaluation of lipid metabolic disorders with superior prognostic value compared to conventional lipid parameters. This study aims to investigate the levels of CAR and AIP in patients with MI and to elucidate their relationships with the extent of coronary artery lesions, quantified by the Gensini score, to enhance diagnostic and prognostic capabilities.

Medical professionals, cardiologists, internal medicine specialists, researchers in cardiovascular diseases, and healthcare policymakers.

This cross-sectional study investigated the diagnostic and prognostic value of the C-reactive protein to albumin ratio (CAR) and the atherogenic index of plasma (AIP) in 180 patients diagnosed with myocardial infarction (MI) at Hue Central Hospital. The research aimed to assess the levels of these indices and their correlation with the severity of coronary artery disease (CAD) as determined by the Gensini score. The methodology involved collecting clinical and biochemical data, including CAR, AIP, and Gensini scores, from March to December 2024. Results indicated mean CAR, AIP, and Gensini scores of 0.33 ± 0.4 mg/g, 0.17 ± 0.3, and 52.71 ± 35.12, respectively. A significant positive correlation was observed between CAR and inflammatory markers (hs-TnT) and severity scores (Gensini, GRACE), suggesting that elevated CAR levels correspond to more severe cardiac damage and CAD. Similarly, AIP also showed a positive correlation with the Gensini score, highlighting its role in reflecting the extent of atherosclerotic lesions. The study established optimal cut-off values for CAR (≥ 0.274 mg/g) and AIP (≥ 0.39) for predicting severe CAD. Crucially, the combination of CAR and AIP demonstrated superior predictive accuracy (AUC=0.76) compared to either index alone, indicating their synergistic utility. Furthermore, CAR, AIP, and systolic blood pressure (HATT) were identified as independent factors associated with the severity of coronary artery lesions. These findings underscore the importance of CAR and AIP as valuable biomarkers for assessing inflammation, lipid metabolism, and overall prognosis in patients with myocardial infarction, offering improved risk stratification and guiding management strategies.