Tác dụng giảm sưng nề, bầm tím của chế phẩm Dehema trên mô hình chấn thương phần mềm

Soft tissue injuries are a common clinical challenge, often resulting from daily activities, sports, or accidents. These injuries typically manifest as pain, swelling, and bruising, and can lead to severe complications if not properly managed. While modern medicine often relies on non-steroidal anti-inflammatory drugs (NSAIDs) and steroids, these treatments can present undesirable side effects such as gastrointestinal issues or organ dysfunction. In contrast, traditional medicine offers valuable perspectives, with ancient remedies like 'Đào hồng tứ vật thang' emphasizing the importance of activating blood circulation and resolving stasis to alleviate symptoms. DEHEMA, an herbal product derived from such a classical formula, represents a promising alternative. This study aimed to evaluate the anti-swelling and anti-bruising effects of DEHEMA in a soft tissue injury model, seeking to provide scientific evidence for its therapeutic potential.

Researchers in pharmacology, traditional medicine practitioners, pharmacists, clinicians specializing in injury management, and developers of herbal remedies.

Soft tissue injuries pose a significant health concern due to their high prevalence and potential for complications like prolonged pain, swelling, and bruising. Current Western medical approaches often involve medications with known side effects. This research investigates DEHEMA, an herbal preparation rooted in traditional medicine, specifically adapted from the ancient 'Đào hồng tứ vật thang' formula, renowned for its efficacy in promoting blood circulation and resolving stasis. The study's primary objective was to rigorously assess DEHEMA's anti-swelling and anti-bruising properties within a controlled soft tissue injury model. To achieve this, an experimental design utilized rabbits subjected to soft tissue trauma on their ears. These animals were subsequently treated for 10 consecutive days with either two different doses of DEHEMA (6 ml/kg/day or 12 ml/kg/day) or Celecoxib (24 mg/kg/day) as a reference drug. Throughout the treatment period, researchers meticulously observed lesion characteristics, measured ear thickness, and quantified the damaged area. The results demonstrated that both DEHEMA doses significantly accelerated damage recovery, notably reducing bruising and congestion when compared to the untreated model group. Statistical analysis confirmed a significant reduction in ear thickness and lesion area in the DEHEMA-treated groups from 3 to 7 days post-injury (p < 0.05). Importantly, DEHEMA's therapeutic effects were comparable to those of Celecoxib (p > 0.05), suggesting a similar level of effectiveness without significant differences between its two tested dosages. These findings underscore DEHEMA's potential as an effective and well-tolerated treatment for soft tissue injuries, offering a valuable, traditionally-inspired alternative or complementary therapy that could mitigate the side effects associated with conventional anti-inflammatory drugs, thereby improving patient outcomes.