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Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1)

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:8

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The trypsin-like serine protease hepatocyte growth factor activator (HGFA) undergoes proteolytic activation during blood coagulation, result-ing in a 34 kDa ‘short form’, consisting mainly of the protease domain. The crystal structures of the recombinantly expressed HGFA ‘short form’ discussed herein have provided molecular insights into its interaction with inhibitors and substrates, as well as the regulation of catalytic activity.

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Nội dung Text: Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1)

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