Báo cáo khoa học: Purification, characterization and biosynthesis of parabutoxin 3, a component of Parabuthus transvaalicus venom
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A novel peptidyl inhibitor of voltage-gated K + channels, named parabutoxin 3 (PBTx3), has been puri®ed to homo-geneity from the venom ofParabuthus transvaalicus.This scorpion toxin contains 37 residues, has a mass of 4274 Da and displays 41% identity with charybdotoxin (ChTx, also called Ôa-KTx1.1Õ). PBTx3 is the tenth member (called Ôa-KTx1.10Õ)ofsubfamily1ofK + channel-blocking pep-tidesknown thus far.
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