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Báo cáo Y học: The solution structure of gomesin, an antimicrobial cysteine-rich peptide from the spider

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:9

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Gomesin is the first peptide isolated from spider exhibiting antimicrobial activities. This highly cationic peptide is composed of 18 amino-acid residues including four cysteines forming two disulfide linkages. The solution structure of gomesin has been determined using proton two-dimensional NMR (2D-NMR) and restrained molecular dynamics calculations. The global fold of gomesin consists in a wellresolved two-stranded antiparallel b sheet connected by a noncanonical b turn.

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Nội dung Text: Báo cáo Y học: The solution structure of gomesin, an antimicrobial cysteine-rich peptide from the spider

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