MINISTRY OF EDUCATION AND
TRAINING
MINISTRY OF
HEALTH
HANOI MEDICAL UNIVERSITY
DONG THI MAI HUONG
CLINICAL OUTCOMES AFTER SURGICAL TREATMENT
OF CHRONIC PERIODOTAL WITH ENAMEL MATRIX
DERIVATIVES- EMDOGAIN
Specialty : Odontostomatology
Number : 62720601
SUMMARY OF Ph.D. THESIS
HANOI - 2021
THIS RESEARCH WAS PERFORMED AT
HANOI MEDICAL UNIVERSITY
Supervisors:
1. Prof. Trinh Dinh Hai
2. Ph.D. Nguyen Thi Hong Minh
Reviewer 1: Assoc. Prof. Dr. Pham Thi Thu Hien
Reviewer 2: Assoc. Prof. Dr. Le Thi Thu Ha
Reviewer 3: Assoc. Prof. Dr. Tong Minh Son
Thesis will be defended in front of the University Thesis Evaluation
Council
Organized in Hanoi Medical University
At , on , 2021
This thesis can be found at:
1. Vietnam National Library
2. Library of Hanoi Medical University
PUBLISHED RESEARCHES THAT ARE RELEVANT
TO CONTENT OF THIS THESIS
1. Dong Thi Mai Huong (2020). Clinical Outcomes After Sugery
Treatment Of Chronic Periodotal With Enamel Matrix
Derivatives- Emdogain. Medical Research Journal, 132 (8). 45-54.
2. Dong Thi Mai Huong, Trinh Đinh Hai, Nguyen Thi Hong Minh
(2020). Clinical, X-Ray Characteristics And Treatment Results
Of Chronic Periodontis Surgery. Medical Research Journal, 135
(11). 197-204.
1
A. INTRODUCTION
RATIONALE OF THIS THESIS
Periodontitis is a common disease of the Odontostomatology. The
disease occurs in all ages, and countries all over the world, accounted for
a high proportion in the community and of a social nature. In the USA,
research by Walter et al showed that the rate of periodontitis in the
community is 25-41%. In Vietnam, according to the 2001 National Oral
Health Survey, the percentage of people with gingivitis and periodontitis
up to 90%, of which the rate of people with periodontitis at the age of 35-
44 is 36.4%; at the age of 45 and over is 46.2%. Up till now, the
treatment of periodontitis is still facing many difficulties because of the
complication of the disease and their pathogenesis, there is no specific
treatment, but treatment for periodontitis includes a complex treatment
consisting of many methods. In which there are two main methods are
conservative treatment and surgical treatment. Periodontitis conservative
or non-surgical treatment is a complex treatment, it offers good results
for early periodontitis with periostal sac less than 5mm. Periodontitis
with a pocket around the tooth over 5mm must be combined with
surgical treatments to eliminate inflammatory factors, necrotic tissues,
prevent the inflammatory process and reduce the depth pocket. In
addition, periodontal surgery also regenerates tissue around the teeth with
good results to restore the function and aesthetics of the patient. One of
the purposes of periodontitis treatment is to restore damaged tissue. The
proteins of Enamel Matrix Derivatives, which are formed from the
Hertwig epithelium at the time of root formation, create a mutual action
of the cell to form cement, especially the noncellular cement and then to
form attachment fibers. In the treatment of periodontitis the proteins are
beneficial to stimulate the regeneration of these tissues, direct the healing
to the formation of new cement, functional new adhesion and new bones.
Globally, there are many studies on the treatment of periodontitis with
regeneration of periodontal tissue with very high results from enamel
derivatives - Emdogain, opening a new direction for treatment of
periodontitis. However, in Vietnam, there are still no research works on
this issue, so we conduct research on the topic: “Clinical Outcome After
Surgical Treatment Of Chronic Periodotal With Enamel Matrix
Derivatives- Emdogain”. With the following goals:
1. Comment on clinical, X-ray of stage IV chronic periodontitis
according to AAP of a group of patients at Hanoi Central
Odontostomatology Hospital from 2016-2019.
2. Evaluation of surgical treatment results for chronic periodontitis
using enamel matrix derivatives - Emdogain on the control group of
patients.
2
URGENCY OF THE TOPIC
Periodontitis is a common disease especially in Vietnam, according
to the 2001 National Oral Health Survey, the rate of people with
gingivitis and periodontitis up to 90%. Inflammation around the teeth
causes bone resorption, loss of gums, moving teeth leading to tooth loss.
There are a variety of therapeutic, surgical and non-surgical treatments
for periodontitis, with the goal of preventing the destruction of the
periodontal tissue and in some cases, attempting to regenerate the
periodontal tissue. Emdogain is a gel protein that helps preserve
periodontal tissue by promoting the regeneration of soft and hard tissues
of the tooth organization destroyed by inflammation around the tooth.
Lots of clinical studies have proven safe and effective results in forming
new periodontal tissue. In Vietnam, there are many studies on renewable
materials, but there are no studies on the application of Emdogain, so the
topic is urgent to help dentists with more options in the treatment
periodontitis
PRACTICAL MEANING AND NEW CONTRIBUTION
Since the early twentieth century, many surgical methods have been
introduced to treat periodontitis and bring about encouraging results.
However, these methods are still limited in the regeneration of
periodontal tissue. Many grafting materials in periodontal surgeries are
studied in the second half of the XX century have yielded superior results
in tissue regeneration compared to simple flap surgery. Emdogain
stimulates production of collagen, cement cells and alveolar bone cells
on the root surface. Emdogain has been researched and used in developed
countries, but in Vietnam, there has been no research application of this
product in the treatment periodontitis. So this study has high practical
significance and has made a new contribution to the treatment
periodontitis in Vietnam.
THESIS STRUCTURE
The thesis includes 122 pages, Background (2 pages), Overview (39
pages), Subjects and methods (20 pages), results (32 pages), discussion
(27 pages), conclusion (1 pages) and recommendation (1 page). The
whole thesis includes 38 tables, 15 figures, 6 charts. The number of
references are 87 (15 Vietnamese and 72 English)