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INTRODUCTION
Diabetes is one of the three most developping diseases in
the world. According to the WHO announcement in 2014, there
were 422 millions diabetes patients, taking account to 8,5%
population. The prevalence has increased through three
decades, especially in the poor and developing countries.
The increase of diabetes prevanlence also accords to its
complication. It is the cause of cardiovascular accidents,
blindness, renal failure, amputation and others which reduce
life quality. In 2015, the association of foot wound, the foot
complication of diabetes has enormously affected the national
economics, the prevalence in the developed country is about
2% to 4%, and could be higher in the developing country. The
worldwide rate of diabetic foot ulcer is 6,3%, male is higher
than female, type 2 higher than type 1. The North America had
highest prevalence 13%, then Australia 3,0%; Asia 5,5%,
Africa 7,1%, European 5,1%. In India, about 5% diabetic
patients have the foot wound. The porpotion of amputation in
diabetic foot complication is 40%. In the developping country
like England, 50% diabetics patients were admitted because of
foot wound. Another research in 6000 patients showed that foot
ulcer was 20% and amputation was 2,5% .
In many researches of the Vietnam National Hospital of
Endocrinology showed that the prevalence of late stage diabetic
patients with the foot and amputation complications was high
(about 40%).
The foot complication is the consequence of causes such
as: nerves, vessels, injuries, trauma and infection. The diabetic
foot complication mechanism is the close combination of three
factors: vascular, nerve injuries and infection, sometimes these
factors could appear independently. Some studies showed that
the pressure points of foot have a close relationship with the
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foot ulcer. Therefore, the plantar pressure is the predictive
factor in diabetic foot complication patients.
However, there is no research which evaluates the change
of plantar pressure in term of recognization, prevention and
reduce the foot injuries of diabetic patients.
This thesis “Assessment of the plantar pressure in the
relation with nerve conduction, and ankle-brachial index
(ABI) in type 2 diabetes patients” aims to:
1. Assessment the plantar pressure and some nerve
conduction index, ankle-brachial index in type 2 diabetes
patients.
2. Evaluation the relation between the plantar pressure,
nerve conduction index, ankle-brachial index and
characteristics in type 2 diabetes patients.
The new contribution of the thesis:
-This thesis showed that the prevalence of increase plantar
pressure measured in the base of the first toe in the diabetic
patients was 79,4% and base of the third toe was 44,4%.
-The plantar pressure increased with the level of nerve injury. It
was statistically significant between the plantar pressure and
the potential nerve conduction.
-The plantar pressure in diabetic patients increases with the
level of peripheral artery (assessed by the ABI), significantly
positive correlation with the plantar pressure of the second,
third and fifth toes (assessed by the ABI).
Structure of the thesis
This thesis includes 122 pages: Introduction 2 pages,
General description 34 pages, Subjects and Methodology 21
pages, Result 30 pages, Discussion 33 pages, Conclusion 1
page, Proposal 1 page, 52 tables, 5 graphs, 1 map, 12 pictures,
122 references (33 Vietnamese, 90 English).
Chapter 1: GENERAL DESCRIPTION
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1.1 DIABETES
1.1.1 Definition
Diabetes is the metabolic disorder, characterized by the
hyperglycemia caused by the shortage of insulin secretion, the
action of insulin or both. The long term hyperglycemia leads to
others metabolic disorders such as metabolism of carbohydrate,
protein, and lipid, which lead to others organs injuries,
especially cardiovascular, renal, ophthalmologic, neurologic
diseases.
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1.1.2 Risk factors
The risks factors of type 2 diabetes are classified in four
categories: genetics, human race, habits, lifestyle, and
intermediate risks.
Genetic factors
Human race (age, gender, race)
Lifestyle and habits relating risk factors
Obesity (distribution and related risk factors)
Inactivity
Diet
Others
-Stress
-Lifestyle: urbanization, modernization
-The factors which relate to the gestation such as: status of
delivery, gestation diabetes, diabetes, the next generation of the
diabetic patients, the uterus environment.
1.1.3 The diagnosis criteria of diabetes
-Fasting plasma glucose (FPG) 7mmol/l (126mg/dl). Fasting at
least 8 hours before blood test. Or
-Plasma glucose after 2 hours 11,1 mmol/l ( 200mg/dl) with
the oral glucose tolerance test (WHO), 75 g glucose (anhydrous
glucose) diluted in 200 ml water. Or
-HbA1c 6,5 % (48mmol/mol), blood test approved by the NGSP
and standardized in DCCT assay
Or
- Typical signs and symptoms of hyperglycemia (polyuria,
polydipsia, polyphagia, lose weight), beside HbA1c, there
are others tests have to be re-done to confirm the diagnosis.
The second time doing the test should be further from the
first time 1-7 days.
1.2. The plantar pressure
1.2.1. Definition
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-The maximum pressure which directly contacts to the ground, is
weighted to the foot in standing position on the flat surface.
-Peak pressure is the pressure to a square unit. It is counted by
the division of total pressure to the total affected square.