International University
Biotechnology
Biochemistry
Lecturer: Msc. Le Hong Phu
Topic 9: Detailed
Mechanism of Enzyme
Catalyst
•Group Members:
1. Do Ngoc Anh Huy
2. Tran Van Kha
3. Doan Luong Huy
4. Dang Duong
5. Nguyen Quang Toan
6. Nguyen Thi Huong Giang
7. Pham Vinh Phuoc
Group leader
Content:
•Definition and basic process:
1. Induced fit
2. Mechanisms of transition state stabilization
•Detailed in example to make you
understand more about mechanism of
enzyme catalyst:
Chymotripsin
Lock-key theory
•A Specific active site for a specific substrate
How can make the
key to be fixed to the
locker???
Induced fit theory
•The initial reaction between E and S is weak, but it
rapidly induce by conformational changes in the enzyme.