Tác dụng cải thiện dự trữ buồng trứng của bài thuốc Tự Hoài: Góc nhìn kết hợp Đông – Tây y

Diminished Ovarian Reserve (DOR) represents a significant challenge in reproductive medicine, characterized by a decline in both the quality and quantity of ovarian follicles. This condition profoundly impacts women's quality of life and reproductive health, yet specific treatment guidelines and a comprehensive understanding of its complex etiology remain elusive. Traditional Chinese Medicine (TCM) offers promising avenues, and the Zihuai formula, a compound of herbs known for tonifying liver and kidney functions, regulating menstruation, strengthening the spleen, and nourishing blood, has demonstrated therapeutic potential. This paper seeks to elucidate the mechanisms underlying Zihuai's effects on reproductive hormones and ovarian follicle indices, integrating both modern pharmacological insights and traditional medical perspectives to bridge the understanding between these two systems.

Academics and clinicians in reproductive medicine, specifically those interested in integrating Traditional Chinese Medicine and Western medical approaches for ovarian dysfunction.

Diminished Ovarian Reserve (DOR) poses a considerable obstacle to reproductive health, stemming from its complex and multifactorial etiology that currently lacks a standardized treatment approach. This study investigates the Zihuai formula, a traditional Chinese herbal preparation, as a potential therapeutic intervention for DOR. Comprising herbs traditionally believed to tonify the liver and kidneys, regulate menstruation, strengthen the spleen, and nourish the blood, the Zihuai formula has shown remarkable therapeutic outcomes in an experimental animal model of DOR conducted at Guangzhou University of Chinese Medicine. Specifically, it demonstrated positive effects on reproductive hormones and ovarian follicle indices, suggesting an improvement in ovarian function. The research meticulously clarifies these observed effects by integrating both modern Western medicine and traditional Chinese medicine perspectives. Through a pharmacological lens, the study explores how individual components of Zihuai contribute to anti-oxidative, anti-inflammatory, and anti-apoptotic processes, alongside their roles in hormonal regulation, thereby protecting ovarian cells and enhancing follicle development. Concurrently, it aligns these modern findings with TCM principles, emphasizing the formula's ability to address underlying imbalances such as kidney essence deficiency, spleen qi deficiency, and liver qi stagnation, which are implicated in DOR pathogenesis. By correlating the mechanisms across both medical systems, this paper provides a scientific basis for the clinical application of the Zihuai formula, offering a holistic and potentially effective strategy to improve ovarian reserve and reproductive outcomes for women facing this challenging condition, thereby enhancing its applicability in diverse clinical settings.