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báo cáo khoa hoc : Biological validation that SF3b is a target of the antitumor macrolide pladienolide
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Pladienolide is a naturally occurring macrolide that binds to the SF3b com-plex to inhibit mRNA splicing. It has not been fully validated whether the splicing impairment is a relevant mechanism for the potent antitumor activ-ity of pladienolide.
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