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Báo cáo khoa học: A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+
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Stromal interaction molecule 1 (STIM1) is responsible for activating the Ca 2+ release-activated Ca 2+ (CRAC) channel by first sensing the changes in Ca 2+ concentration in the endoplasmic reticulum ([Ca 2+ ]ER) via its luminal canonical EF-hand motif and subsequently oligomerizing to inter-act with the CRAC channel pore-forming subunit Orai1.
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