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báo cáo khoa học: " Correction: EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features"

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Li et al. Journal of Experimental & Clinical Cancer Research 2011, 30:32 http://www.jeccr.com/content/30/1/32 CORRECTION Open Access Correction: EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features Feng Li1, Yongmei Liu1, Huijiao Chen2, Dianying Liao2, Yali Shen1, Feng Xu1*†, Jin Wang1*† Correction Which should have been: “The positive rate of EGFR protein in NSCLC tumor In the article [1] there were errors in Tables three, four, cells were 46%, which was significantly higher than its five, six and seven. The incorrect values were produced expression in normal lung (p = 0.034) and paracancer- due to typographical errors during translation stage. ous (p = 0.020)” These errors affect neither the published discussion nor Under the heading “ Correlation between EGFR the conclusions of the paper. However, a few changes to expression and clinical features“ The second sentence the results section are detailed here. read: “It shows that the difference of EGFR expression In the Abstract, under “Results” the first two was only significant between the nodal positive and negative subgroups (56.4% vs.10%, p = 0.04).” sentences read But the passage should have been “The expression of “ The positive rate of EGFR protein in NSCLC tumor EGFR in different subgroups were compared and sum- cells was 46%, which was significantly higher than its marized in Table three. It shows that the difference of expression in normal lung (p = 0.0234) and paracancer- EGFR expression was only significant between the nodal ous tissues (p = 0.020). EGFR expression was signifi- positive and negative subgroups (56.4% vs. 9.1%, p = cantly higher in nodal positive than in nodal negative patients (p = 0.04).” 0.006). There is no significant difference between age (60 vs. under 60 ys), gender, adeno- vs. non-adenocarci- But should have been: noma, the differentiation of tumor, and staging.” “The positive rate of EGFR protein in NSCLC tumor This is the correct table three (table 1). cells was 46%, which was significantly higher than its Correct tables four (table 2), five (table 3) and six expression in normal lung (p = 0.034) and paracancer- (table 4). ous tissues (p = 0.020). EGFR expression was signifi- Under the heading “Correlation of EGFR and COX-2 cantly higher in nodal positive than in nodal negative expression “ The sentence reads: “ As shown in Table patients (p = 0.006).” seven, no correlation was found between COX-2 and In the main “Results” section of the article EGFR protein expression (Χ2 = 0.112, P = 0.555).” But should have read: “As shown in Table seven, no The sentence under the heading “EGFR protein expres- sion “ read: “ The positive rate of EGFR protein in correlation was found between COX-2 and EGFR pro- tein expression (P > 0.05).” NSCLC tumor cells were 46%, which was significantly Correct table seven (Table 5). higher than its expression in normal lung (p = 0.0234) and paracancerous (p = 0.020)” * Correspondence: Fengxuster@gmail.com; jinwang593@yahoo.com.cn † Contributed equally 1 Radiation Oncology, Tumor Center, West China Hospital, Sichuan University, PR China Full list of author information is available at the end of the article © 2011 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Li et al. Journal of Experimental & Clinical Cancer Research 2011, 30:32 Page 2 of 2 http://www.jeccr.com/content/30/1/32 Table 1 (corrected table 3). EGFR expression and clinical Table 4 (corrected table six) 6 COX-2 expression and characteristics correlation with clinical features P P Clinical features EGFR Positive Clinical features COX-2 Positive expression rate value expression rate value negative positive negative positive Ages 0.448 Ages 0.599 ≤60 < 60 18 14 43.80% 3 30 90.90% ≥60 9 9 50% > 60 2 15 88.20% Sex 0.445 Sex 0.362 Male 16 15 48.40% Male 4 27 87.10% Female 11 8 42.10% Female 1 18 94.70% Pathologic type 0.543 Pathologic type 0.022* Squamous carcinoma 13 8 38.10% Squamous carcinoma 5 16 76.20% Adencarcinoma 13 13 50.0% Adencarcinoma 0 26 100% Mixed type 1 2 66.70% Mixed type 0 3 100% Tumor length 0.535 Tumor length 0.518 ≤3 cm ≤3 cm 9 7 43.80% 2 14 87.50% > 3 cm 18 16 47.10% > 3 cm 3 31 91.20% Level of Differentiation 0.474 Level of Differentiation 0.258 Poor Differentiated 6 4 40% Poor Differentiated 2 8 80% Moderate and Well 21 19 47.50% Moderate and Well 3 37 92.50% Differentiated Differentiated TNM Stage 0.194 TNM Stage 0.476 I-II 10 5 33.30% I-II 2 13 86.70% III-IV 17 18 51.40% III-IV 3 32 91.40% Lymph node 0.006* Lymph node 0.699 N0 10 1 9.10% N0 1 10 90.90% N1-3 17 22 56.40% N1-3 4 35 89.70% *P < 0.05. *P < 0.05. Table 5 (corrected table seven) Correlation of EGFR and COX-2 protein expression Table 2 (corrected table four) COX-2 expression in neoplastic and normal tissue EGFR Total Tissue type Number COX-2 Positive P negative Positive of cases rate(%) value COX-2 negative 3 2 5 positive negative positive 24 21 45 Neoplastic 50 45 5 90 0.000* Total 27 23 50 tissue There was no significant relationship between COX-2 and EGFR. P > 0.05. Normal 6 0 6 0 tissue Author details P < 0.05. 1 Radiation Oncology, Tumor Center, West China Hospital, Sichuan University, PR China. 2Department of Pathology, West China Hospital, Sichuan University, PR China. Table 3 (corrected table five) COX-2 expression in tumor Received: 28 March 2011 Accepted: 28 March 2011 and paracancerous tissue Published: 28 March 2011 Tissue type Number of COX-2 Positive P Reference cases rate(%) value 1. Li Feng, Liu Yongmei, Chen Huijiao, Liao Dianying, Shen Yali, Xu Feng, positive negative Wang Jin: EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features. Journal of Experimental & Neoplastic 50 45 5 90 0.000* Clinical Cancer Research 2011, 30:27. tissue Paracancerous 7 1 6 14.3 doi:10.1186/1756-9966-30-32 tissue Cite this article as: Li et al.: Correction: EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with P < 0.05. clinical features. Journal of Experimental & Clinical Cancer Research 2011 30:32.

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