Định lượng chì trong cao đặc cây ngũ sắc và một số dược liệu bằng phổ hấp thụ nguyên tử

The increasing global reliance on herbal medicinal products, particularly for chronic conditions like rhinosinusitis, underscores the critical need for robust quality control measures. These natural remedies, while offering therapeutic benefits, are susceptible to contamination by heavy metals such as lead, introduced during cultivation, harvesting, or processing. Lead's severe neurotoxic and systemic effects highlight the imperative for stringent safety assessments to protect public health. This study addresses this vital concern by developing and validating a method for the accurate lead quantification in a specific concentrated herbal extract mixture, ensuring these widely used traditional preparations meet established safety standards.

Researchers in analytical chemistry and pharmacognosy, quality control laboratories for herbal products, pharmaceutical manufacturers, and regulatory bodies overseeing traditional medicine.

This study focused on developing and validating a robust analytical method for lead quantification in concentrated herbal extract mixtures, specifically those formulated for rhinosinusitis and containing Ageratum conyzoides L., Lonicera japonica, Eclipta prostrata, Angelica dahurica, and Asarum sieboldii. Recognizing the potential for heavy metal contamination in herbal products and the associated health risks, the research aimed to ensure the safety and quality of these traditional remedies. The methodology employed flame atomic absorption spectroscopy (FAAS), a widely recognized technique for heavy metal analysis. The analytical method underwent comprehensive validation according to AOAC and ICH guidelines, assessing key parameters such as specificity, accuracy, linearity, repeatability, limit of detection (LOD), limit of quantitation (LOQ), and system suitability. The validation results were excellent, demonstrating high reliability with an R² value of 0.9992, a mean recovery of 101%, and a relative standard deviation (RSD) below 2%. The method achieved a low LOD of 0.0427 ppm and LOQ of 0.1409 ppm, confirming its sensitivity and precision for trace element analysis. Crucially, the lead concentrations detected in all analyzed herbal extract samples ranged from 0.10-0.12 ppm. These levels were found to be substantially lower than the permissible regulatory limit of 20.0 ppm, indicating the samples’ compliance with safety standards. This validated flame atomic absorption spectroscopy method provides a highly accurate and sensitive tool for routine quality control of lead in herbal extracts, offering significant implications for ensuring consumer safety and supporting regulatory oversight in the burgeoning herbal medicine market.