Nghiên cứu bào chế cao đặc tỏi từ dược liệu tỏi (Allium sativum L.) thu hái trên địa bàn tỉnh Hải Dương

Garlic (Allium sativum L.) has long been recognized for its diverse medicinal properties, including antibacterial, antifungal, antioxidant, and cardiovascular benefits, largely attributed to active compounds like allicin and polyphenols. However, the traditional use of fresh or dried garlic powder presents challenges such as strong pungent odor, inconsistent active ingredient content, and instability during storage and processing. These limitations hinder its integration into modern pharmaceutical applications. Therefore, developing standardized forms like concentrated garlic extract is crucial. This study aims to address these issues by establishing an optimal formulation and preparation process for concentrated garlic extract, alongside defining its quality standards, to enhance its therapeutic potential and applicability.

Pharmaceutical researchers, pharmacologists, quality control specialists, and manufacturers of herbal extracts and health products.

This research successfully developed a robust process for preparing concentrated garlic extract from Allium sativum L. harvested in Hai Duong province and established its comprehensive quality standards. The methodology centered on optimizing the cold maceration method. Specifically, dried garlic material was coarsely ground, then macerated twice for 24 hours in 70% ethanol at a drug-to-solvent ratio of 5/1. Following extraction, the solvent was recovered by distillation, and the resulting extract was concentrated and dried at 50°C to yield a thick, stable substance with a moisture content below 20%, suitable for storage under controlled conditions. The quality assessment adhered to Vietnamese Pharmacopoeia V standards, evaluating organoleptic properties, moisture content, qualitative and quantitative analyses, insoluble matter, solubility, pH, total ash, heavy metal limits, and microbiological purity. The optimized process yielded a final product that met all predefined quality criteria, notably demonstrating a high polyphenol content and excellent stability under specified storage conditions. This concentrated garlic extract offers significant advantages over fresh or powdered garlic by mitigating its pungent odor, ensuring more consistent active ingredient levels, improving stability, and facilitating its incorporation into modern drug formulations and health protection products. The findings provide a crucial scientific basis for the standardized production and diversification of garlic-derived medicinal products.