Khảo sát một số chỉ tiêu chất lượng cao đặc từ ngũ sắc và một số dược liệu

The global prevalence of rhinosinusitis, coupled with the limitations of conventional treatments regarding cost and side effects, underscores an urgent need for safe, effective, and accessible alternative therapies, particularly from traditional herbal medicine. This study addresses this critical demand by investigating a traditional herbal formula containing Ageratum conyzoides (Ngũ sắc) and other selected medicinal plants, traditionally used for rhinosinusitis support. The primary objective is to thoroughly evaluate the selected quality parameters of its concentrated extract, which is essential for establishing robust quality control benchmarks. This research is instrumental in advancing the standardization and development of herbal products for therapeutic applications.

Researchers in pharmaceutical sciences, pharmacognosy, traditional medicine, quality control laboratories, and regulatory bodies involved in herbal product development and standardization.

This study systematically evaluated the quality parameters of a concentrated extract derived from a traditional herbal formula comprising Ageratum conyzoides (Ngũ sắc) and four other medicinal plants, with potential applications in rhinosinusitis management. The comprehensive methodology involved sensory evaluation, determination of loss on drying, thin-layer chromatography for qualitative identification, UV-Vis spectrophotometry for quantifying total flavonoids, atomic absorption spectrophotometry to assess heavy metal (lead) limits, and analyses for total ash and microbial limits. All procedures adhered to the stringent requirements of the Vietnamese Pharmacopoeia V. The results unequivocally demonstrated that the concentrated extract successfully met all established general quality criteria. Specifically, it exhibited satisfactory organoleptic properties, acceptable moisture content (below 20%), positive identification of components from the five constituent herbs, a total flavonoid content ranging from 3.01-3.10%, undetectable levels of lead, total ash content within permissible limits (below 5%), and compliance with microbial limits. These findings are crucial as they provide a foundational scientific basis for proposing specific quality standards and analytical methods for the routine quality control of this concentrated extract. This work is vital for ensuring the safety, efficacy, and consistency of traditional herbal products, thereby facilitating their integration into modern healthcare practices.