Nghiên cứu điều chế cao đặc giàu flavonoid của bài thuốc từ cây ngũ sắc và một số dược liệu

In the realm of traditional medicine, herbal formulations often provide valuable therapeutic benefits, yet their widespread application can be limited by time-consuming and variable preparation methods. Flavonoids, known for their potent anti-inflammatory, antioxidant, and antibacterial properties, are key active compounds in many medicinal plants, including Ageratum conyzoides and several other selected herbs used in Vietnamese traditional remedies. Developing a standardized and efficient process for extracting these beneficial compounds is crucial for enhancing the efficacy and accessibility of herbal treatments. This study addresses this need by focusing on the optimization of extraction and preparation parameters to yield a high-quality, flavonoid-rich concentrated extract from these traditional medicinal plants, aiming to establish a robust foundation for future product development.

Researchers and practitioners in herbal medicine, pharmaceutical scientists, and professionals in natural product development.

This research meticulously investigated factors influencing the extraction and preparation of a flavonoid-rich concentrated extract derived from Ageratum conyzoides and a combination of other medicinal herbs traditionally used for conditions like sinusitis. Employing a systematic one-factor-at-a-time experimental design, the study optimized critical parameters such as solvent concentration, extraction time, solvent-to-raw material ratio, raw material size, and concentration temperature. The methodology involved maceration at room temperature, two consecutive 24-hour extraction cycles using 70% ethanol, and subsequent concentration at 50°C. The findings demonstrate that the optimal conditions for producing the concentrated extract include using 70% ethanol as the solvent, an extraction time of 24 hours per cycle for two cycles, a solvent-to-raw material ratio of 6 ml/g, and a raw material size of 1-3 cm, with no preservatives added during concentration at 50°C. Under these optimized parameters, the process yielded a concentrated extract with a remarkable 30.07% yield and a high total flavonoid-rich content of 3.06%. The stability and reproducibility of this optimized process were further confirmed through a successful scale-up to 200g batches. This comprehensive study provides a robust, standardized procedure for the efficient preparation of a flavonoid-rich concentrated extract, offering a significant advancement in the development of scientifically validated and quality-controlled herbal remedies, particularly for supportive treatment of inflammatory conditions.