Master's thesis of Science (Applied Biology & Biotechnology): Synthesis and characterisation of epigallocatechin gallate (EGCg) conjugated gold nanoparticles and their effect on cellular migration and cancer invasion

Studies on nanoparticle-protein interaction have also not been studied. This would give information on ratio influence on the structural alteration of EGCg in EGCg-AuNPs and its functionality in vivo. Herein, the optimisation of EGCg-AuNPs will be determined with a large pool of stoichiometric synthesises of gold and EGCg. These optimised EGCg-AuNPs would then be studied with bovine serum albumin (BSA) for protein interactions, binding and thermodynamics. These would also be compared with pristine EGCg and studied in MDAMB-231 breast cancer cells. This study will increase the understanding of the regulation of proteins that promote cancer cell invasion and migration and analysis of the changes in gene expression.