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CHAPTER 5. PENTOSE PHOSPHATE
PATHWAY
INTERNATIONAL UNIVERSITY
SCHOOL OF BIOTECHNOLOGY
BIOCHEMISTRY
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Learning objectives
To know the enzyme joining the PPP
To understand the pathways to form the
ribose 5-phosphate
To understand the regulation of PPP
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Content
Functions of the pentose phosphate
pathway
Oxidative reactions leading from
glucose 6-phosphate to ribose 5-
phosphate
Non-oxidative reactions leading to the
formation of intermediates of glycolysis
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glucose glucose pentose
6-phosphate phosphate
pathway
glycogen
glycolysis
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FUNCTIONS OF THE PENTOSE PHOSPHATE
PATHWAY
Provide reduced NADP for synthetic
reactions, e.g. fatty acid synthesis and
reduction of glutathione
Provide pentose phosphate for nucleic
acid synthesis