Vietnam National University HCMC
International University
The Role of Cofactor in Enzyme Catalysis
Group’s members:
Bùi Minh Ph ng ươ
D nươ g Hoàng B o Khánhả
Đoàn Võ Thùy Linh
Ngô Lâm Viên
Phùng Đan Tâm
Đoàn Tây Nguyên
Nguy n Đ c Thanh Longễ ứ
CONTENTS
1.What is Cofactor?
2.Classification
3.Role of Cofactor in Enzyme Catalysis
I. What is cofactor ?
•Non-protein chemical compound
1. Organic group (coenzymes & prosthetic groups )
2. Inorganic group
•Help enzyme work but not have any chemical
reaction to enzyme molecule.
1. Holoenzyme: active (with cofactor )
2. Apoenzyme: inactive (without cofactor)
•Apoenzyme + Cofactor = Holoenzyme
I. What is cofactor ?
•Cofactor need to get from outside environment -> can’t
synthesize in body.
•One enzyme requires many cofactors .
•One cofactor can join with many enzyme.
⇒Lack of one cofactor will stop many metabolism pathways.
I. What is cofactor ?