Free energy landscape

Part 2 of ebook "Non-equilibrium thermodynamics and the production of entropy: Life, earth, and beyond" provides readers with contents including: thermodynamics of the ocean circulation, a global perspective on the ocean system and living systems; entropy and the shaping of the landscape by water; entropy production in the planetary context; the free-energy transduction and entropy production in initial photosynthetic reactions;...

135p dongmelo 26-05-2024 4 2   Download

Computational approaches for the determination of biologically-active/native three-dimensional structures of proteins with novel sequences have to handle several challenges. The (conformation) space of possible three-dimensional spatial arrangements of the chain of amino acids that constitute a protein molecule is vast and highdimensional.

17p vijisoo2711 27-10-2020 12 0   Download

A folding RNA molecule encounters multiple opportunities to form non-native yet energetically favorable pairings of nucleotide sequences. Given this forbidding free-energy landscape, mechanisms have evolved that contribute to a directed and efficient folding process, including catalytic proteins and error-detecting chaperones.

13p vicolorado2711 23-10-2020 11 3   Download

The transition state region on the free energy surface then was sampled by using umbrella sampling technique. We show that the transition state ensemble is broad consisting of different conformations that have different folded and unfolded elements.

11p viaphrodite2711 14-10-2019 14 1   Download

In this study, we investigate the role of amino a id sequen es in the folding of proteins. We onsider two models that are diered by sequen espe iity: the tube HP model with hydrophobi (H) and polar (P) sequen es, and the tube Go model with native- entri onta t potentials

7p thuyliebe 12-10-2018 19 0   Download