Mechanism of cell killing

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Master's thesis of Applied Science (Medical and Health Physics): Investigation of dose distribution to breasts in coronary angiography

The purpose of the study is to quantify breast dose to reassure patients and staff that these understandings still apply. A combination of measurements and simulations were used to estimate absorbed breast dose. Gafchromic® XR-QA2 film was used to measure breast dose placed inside the RANDO® phantom in a series of controlled experiments. The RANDO® is an anthropomorphic phantom commonly used for dosimetry investigations. Gafchromic® XR QA2 film is a radiochromic film that changes colour when irradiated. Simulation is commonly used and readily available.

195p runthenight05 01-03-2023 7 3 Download

Báo cáo khoa học: Etoposide upregulates Bax-enhancing tumour necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has attractedmuch attention because of its ability to kill tumour cells. In this study, we demonstrated that treatment of QGY-7703 cells with the combination of TRAIL and etoposide resulted in synergistic cytotoxic effects. In dissecting the mechanism underlying this syner-gistic effect, we found that treatment with etoposide alone resulted in the upregulation of Bax, while the level of trun-catedBid (tBid)wasunchanged.

11p fptmusic 16-04-2013 38 3 Download