Metazoan systems

Geodin is a protein encoded by a sponge gene homologous to genes from the bc-crystallins superfamily. The interest for this crystallin-type protein stems from the phylogenesis of porifera, commonly called sponges, the earliest divergence event in the history of metazoans. Here we report the preparation of geodin as a recombinant protein fromEscherichia coli, its characterization through physico-chemical analyses, and a model of its 3D structure based on homology modelling.

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Several acute lymphoblastic and myelogenous leukemias are correlated with alterations in the human mixed lineage leukemia protein-1 (MLL1) gene. MLL1 is a member of the evolutionarily conserved SET1 family of histone H3 lysine 4 (H3K4) methyltransferases, which are required for the regula-tion of distinct groups of developmentally regulated genes in metazoans.

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Aidan Budd*, Stephanie Blandin*, Elena A Levashina† and Toby J Gibson* Addresses: *European Molecular Biology Laboratory, 69012 Heidelberg, Germany. †UPR 9022 du CNRS, IBMC, rue René Descartes, F-67087 Strasbourg CEDEX, France. Correspondence: Toby J Gibson. E-mail: toby.gibson@embl.de reviews Published: 26 May 2004 Genome Biology 2004, 5:R38 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/6/R38 Received: 20 February 2004 Revised: 2 April 2004 Accepted: 8 April 2004 © 2004 Budd et al.

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reviews Address: Molecular Biology Institute, Center for Genomics and Proteomics, Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095-1570, USA. Correspondence: Christopher Lee. E-mail: leec@mbi.ucla.edu reports Posted: 29 April 2004 Genome Biology 2004, 5:P12 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/6/P12 © 2004 BioMed Central Ltd Received: 27 April 2004 This is the first version of this article to be made available publicly.

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Meeting report Genomic, chromosomal and allelic assessment of the amazing diversity of maize Virginia Walbot Address: Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA. E-mail: walbot@stanford.edu comment Published: 28 May 2004 reviews Genome Biology 2004, 5:328 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/6/328 © 2004 BioMed Central Ltd A report on the 46th Annual Maize Genetics Conference, Mexico City, Mexico, 11-14 March 2004.

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Meeting report A burst of energy in metabolic disease research Jaswinder K Sethi Address: Department of Clinical Biochemistry, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QR, UK. E-mail: jks30@cam.ac.uk comment Published: 27 May 2004 Genome Biology 2004, 5:327 The electronic version of this article is the complete one and can be found online at http://genomebiology.

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Published: 26 May 2004 Genome Biology 2004, 5:228 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/6/228 © 2004 BioMed Central Ltd reviews Abstract reports Healing wounds and developing tumors are both sites of dynamic interactions between a variety of cell types. Recent microarray studies comparing wounds and tumors have identified characteristic similarities in gene expression that may prove to be useful for assessing cancer prognosis and for choosing subsequent treatment.

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Published: 27 May 2004 Genome Biology 2004, 5:227 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/6/227 © 2004 BioMed Central Ltd reviews Abstract Separation of cell types and developmental stages in the Arabidopsis root and subsequent expression profiling have yielded a valuable dataset that can be used to select candidate genes for detailed study and to start probing the complexities of gene regulation in plant development.

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Eukaryotic genomes are full of long terminal repeat (LTR) retrotransposons. Although most LTR retrotransposons have common structural features and encode similar genes, there is nonetheless considerable diversity in their genomic organization, reflecting the different strategies they use to proliferate within the genomes of their hosts. reports deposited research Transposons are mobile genetic elements that can multiply in the genome using a variety of mechanisms. Retrotransposons replicate through...

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Optimal use of genome sequences and gene-expression resources requires powerful phenotyping platforms, including those for systematic analysis of metabolite composition. The most used technologies for metabolite profiling, including mass spectral, nuclear magnetic resonance and enzyme-based approaches, have various advantages and disadvantages, and problems can arise with reliability and the interpretation of the huge datasets produced. These

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It happens all the time: a pharmaceutical or biotechnology company will spend ten years and hundreds of millions of dollars on a drug candidate that looks spectacular in animal models of a disease, only to see it fail during clinical trials, either because of unexpected adverse reactions in a small number of patients or a surprising lack of efficacy. For every drug that is approved, on average more than 6,000 new chemical substances are created. Only seven of these ever end up being tested in humans, and only three make it to Phase III clinical trials, the final step before...

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Published: 5 April 2004 Genome Biology 2004, 5:R37 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/5/R37 Received: 15 January 2004 Revised: 26 February 2004 Accepted: 11 March 2004 reports © 2004 Baerends et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and

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Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Harry Hines Boulevard, Dallas, TX 75390, USA. †Frank M. Ryburn Jr. Cardiology Center, University of Texas Southwestern Medical Center, Harry Hines Boulevard, Dallas, TX 75390, USA. ‡Center for Biomedical Inventions, University of Texas Southwestern Medical Center, Harry Hines Boulevard, Dallas, TX 75390, USA. §Department of Biochemistry, University of Texas Southwestern Medical Center, Harry Hines Boulevard, Dallas, TX 75390, USA.

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Published: 16 April 2004 Genome Biology 2004, 5:R35 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/5/R35 Received: 7 January 2004 Revised: 23 February 2004 Accepted: 4 March 2004 reports © 2004 Bowers et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL....

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Center for Translational Respiratory Medicine, Gene Expression Profiling Core, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Hopkins Bayview Circle, Baltimore, MD 21224, USA. †Department of Biostatistics, Johns Hopkins University, Baltimore, MD 21205, USA. ‡Center for Translational Respiratory Medicine, Johns Hopkins University, Eastern Ave, Baltimore, MD 21224, USA. §The Institute for Genomic Research, Medical Center Drive, Rockville, MD 20850, USA.

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Service de Conformation des Macromolécules Biologiques, Centre de Biologie Structurale et Bioinformatique, CP 263, Université Libre de Bruxelles, Bld du Triomphe, B-1050 Bruxelles, Belgium. †Institut Pasteur, Unité d'Expression des Gènes Eucaryotes, Institut Pasteur, rue du Docteur Roux, 75724 Paris Cedex 15, France. Correspondence: Shoshana J Wodak. E-mail: shosh@ucmb.ulb.ac.be reviews Published: 30 April 2004 Genome Biology 2004, 5:R33 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/5/R33...

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Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA. †Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, KS 66160, USA. Correspondence: Galina V Glazko. E-mail: gvg@stowers-institute.org reviews Published: 27 April 2004 Genome Biology 2004, 5:R32 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/5/R32

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Genome Institute of Singapore, Agency for Science, Technology and Research, 60 Biopolis Street, Singapore, 138672. †National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. ‡Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892-4264, USA. Correspondence: Sheue-yann Cheng. E-mail: sycheng@helix.nih.gov

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L Aravind, Lakshminarayan M Iyer, Detlef D Leipe and Eugene V Koonin Address: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. reviews Correspondence: L Aravind. E-mail: aravind@ncbi.nlm.nih.gov Published: 16 April 2004 Genome Biology 2004, 5:R30 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/5/R30 Received: 19 January 2004 Revised: 8 March 2004 Accepted: 11 March 2004 reports © 2004 Aravind et al.

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This information has not been peer-reviewed. Responsibility for the findings rests solely with the author(s). comment Deposited research article AutoPrime: selecting primers for expressed sequences Gunnar Wrobel*‡, Felix Kokocinski†‡ and Peter Lichter† Addresses: *Divisions of Bioinformatics and Biochemistry, Swiss Institute of Bioinformatics, Klingelbergstrasse 50/70, 4056 Basel, Switzerland. †Molecular Genetics, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. ‡These authors contributed equally to this work. Correspondence: Peter Lichter.

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