Pathological factors

The study aimed to evaluate the cachexia status and its associated factors in lung cancer patients. Methods: The cross-sectional study was conducted on 97 lung cancer in patients at the Oncology Center, Military Hospital 103, between 2020 and 2021.

10p viyoko 20-09-2024 3 1   Download

Lymph node metastasis (LNM) status is an important prognostic factor that strongly influences the treatment decision of early gastric cancer (EGC). This study aimed to evaluate the pattern and clinical significance of LNM in EGC. Methods: A total of 354 patients with carcinoma in situ (n =42), EGC (n =312) who underwent radical gastrectomy were enrolled. Their clinicopathological features, pathological reports, and prognostic data were collected and analyzed.

13p vielonmusk 21-01-2022 13 1   Download

Objectives: Identifying the species, distribution, biological characteristics and influential factors to the liver flukes infection rate in cattle the Mekong Delta. Suggesting the treatment methods for infected cattle in Mekong Delta.

25p cotithanh321 06-08-2019 41 4   Download

The objective of the research is: To determine the prevalence of vitamin D insufficiency in pregnant women at the National Hospital of Gynecology & Obstetrics and the National Hospital of Endocrinology; to explore relationships between plasma 25 hydroxy vitamin D concentration in women with gestational diabetes mellitus.

29p change04 08-06-2016 28 3   Download

Metallothioneins (MTs) constitute a family of cysteine-rich metalloproteins involved in cytoprotection during pathology. In mammals there are four isoforms (MT-I )IV), of which MT-I and -II (MT-I + II) are the best characterized MT proteins in the brain. Accumulating studies have demon-strated MT-I + II as multipurpose factors important for host defense responses, immunoregulation, cell survival and brain repair.

14p inspiron33 26-03-2013 30 4   Download

Amyloid-b(Ab) aggregation and amyloid formation are key pathological features of Alzheimer’s disease, and are considered to be two of the major contributing factors to neurodegeneration and dementia. Identification of small molecule inhibitors that are orally available, have low toxicity and high central nervous system bioavailability is one approach to the potential development of a disease-modifying treatment for Alzheimer’s disease.

12p media19 06-03-2013 47 2   Download

Vascular endothelial growth factor (VEGF) family members play impor-tant roles in embryonic development and angiogenesis during wound healing and in pathological conditions such as tumor formation. Parapox-viruses express a new member of the VEGF family which is a functional mitogen that specifically activates VEGF receptor (VEGFR)-2 but not VEGFR-1.

11p media19 05-03-2013 26 3   Download

Nuclear factor-kappaB (NF-jB) has been proposed to serve a dual func-tion as a regulator of neuron survival in pathological conditions associated with neurodegeneration. NF-jB is a transcription family of factors com-prising five different proteins, namely p50, RelA⁄p65, c-Rel, RelB and p52, which can combine differently to form active dimers in response to external stimuli.

9p vinaphone15 27-02-2013 25 3   Download

The angiogenic process in the central nervous system (CNS) is basically regulated by typical angiogenic signaling systems such as vascular endothe-lial growth factor (VEGF)–VEGF receptors and angiopoietin–Tie recep-tors. In addition to regular endothelial–pericyte interaction, the CNS vasculature has a unique system of cell to cell communication between endothelial cells and astrocytes which is known as the blood–brain barrier.

8p vinaphone15 25-02-2013 35 3   Download

Thrombin generation increases in several pathological conditions, including cancer, thromboembolism, diabetes and myeloproliferative syndromes. During tumor development, thrombin levels increase along with several other molecules, including cytokines and angiogenic factors. Under such conditions, it is reasonable to predict that thrombin may recognize new low-affinity substrates that usually are not recognized under low-expression levels conditions.

13p viettel02 22-02-2013 33 3   Download

Accumulation ofb-amyloid protein (Ab) is one of the most important pathological features of Alzheimer’s disease. Although Abinduces neurode-generation in the cortex and hippocampus through several molecular mech-anisms, few studies have evaluated the modulation of transcription factors during Ab-induced neurotoxicity.

10p viettel02 19-02-2013 37 3   Download

Arsenic is a strong stimulus of heme oxygenase (HO)-1 expression in experimental studies in response to oxidative stress caused by a stimulus. A functional GT-repeat polymorphism in the HO-1 gene promoter was inversely correlated to the development of coronary artery disease in diabetics and development of restenosis following angioplasty in patients. The role of this potential vascular protective factor in carotid atherosclerosis remains unclear. We previously reported a graded association of arsenic...

11p toshiba23 18-11-2011 88 2   Download

Harrison's Internal Medicine Chapter 120. Osteomyelitis Osteomyelitis: Introduction Osteomyelitis, an infection of bone, is caused most commonly by pyogenic bacteria and mycobacteria. As a useful framework for evaluating a patient and planning treatment, cases are classified on the basis of the causative agent; the route by which organisms gain access to bone; the duration of infection; the anatomic location of infection; and the local and systemic host factors that have a bearing on pathogenesis and outcome.

5p thanhongan 07-12-2010 52 3   Download

The central mechanism of DIC is the uncontrolled generation of thrombin by exposure of the blood to pathologic levels of tissue factor (Fig. 110-3). Simultaneous suppression of physiologic anticoagulant mechanisms and abnormal fibrinolysis further accelerate the process. Together these abnormalities contribute to systemic fibrin deposition in small and mid-sized vessels. The duration and intensity of the fibrin deposition can compromise the blood supply of many organs, especially the lung, kidney, liver, and brain, with consequent organ failure.

5p thanhongan 07-12-2010 67 3   Download

Bone pain is the most common symptom in myeloma, affecting nearly 70% of patients. The pain usually involves the back and ribs, and unlike the pain of metastatic carcinoma, which often is worse at night, the pain of myeloma is precipitated by movement. Persistent localized pain in a patient with myeloma usually signifies a pathologic fracture. The bone lesions of myeloma are caused by the proliferation of tumor cells, activation of osteoclasts that destroy bone, and suppression of osteoblasts that form new bone.

5p thanhongan 07-12-2010 62 7   Download

Radical Prostatectomy The goal of radical prostatectomy is to excise the cancer completely with a clear margin, to maintain continence by preserving the external sphincter, and to preserve potency by preserving the autonomic nerves in the neurovascular bundle. Radical prostatectomy is advised for patients with a life expectancy of 10 years and is performed using a retropubic, perineal, or laparoscopic approach. Outcomes can be predicted using postoperative nomograms that consider pretreatment factors and the pathologic findings at surgery. PSA failure is defined as a value above 0.

5p konheokonmummim 03-12-2010 81 4   Download

Clinical pharmacology comprises all aspects of the scientific study of drugs in man. Its objective is to optimise drug therapy and it is justified in so far as it is of practical use. Over recent years pharmacology has undergone great expansion resulting from technology that allows the understanding of molecular action and the capacity to exploit this. The potential consequences for therapeutics are enormous. All cellular mechanisms (normal and pathological), in their immense complexity are, in principle, identifiable.

4p bigbaby87 03-09-2010 112 20   Download