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The present study investigated the modulation of autophagy and its impact on the cytotoxicity of AraC toward murine myelogenous leukemia cells (M-NFS-60). Autophagy was inhibited by NH4 Cl or Bafilomycin A1 or enhanced by amino acid starvation, glucose starvation, mild hyperthermia (41 °C), or rapamycin (Rap). Cells were treated with different concentrations, 0 to 2 µM, of AraC in the presence or absence of autophagy modulators.
11p lyhuyenthu 31-01-2023 4 2 Download
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This work presents the logical design, connections between NIM and VME electronic modules, and the data acquisition programming to build a complete detector readout system. The energy resolutions of the Si diodes were less than 0.5% energy of a charged particle, which satisfies the foreseen requirement for the upcoming experiments.
9p visnape 30-01-2023 8 4 Download
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This paper presents an effective frustum culling technique at object level. In the proposed method, the rendered region was frustum culled by objects, so the number of objects to be rendered in each frame was significantly reduced.
13p visirius 19-01-2023 11 4 Download
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β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts.
10p vihermione 06-01-2023 5 2 Download
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Increasing column/tubing aspect ratio has been shown in a feasibility study to improve column efficiency when operating in reversed phase mode. This paper contains a thorough investigation on how increases in mobile phase flow and centrifugal force field affect stationary phase retention and column efficiency (as measured by the resolution between adjacent peaks) for columns wound with rectilinear tubing of different aspect ratio.
11p viginny 23-12-2022 4 3 Download
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Effective preconditioning of neutron diffusion problems is necessary for the development of efficient DSA schemes for neutron transport problems. This paper uses P-multigrid techniques to expand two preconditioners designed to solve the MIP diffusion neutron diffusion equation with a discontinuous Galerkin (DG-FEM) framework using first-order elements.
10p vironald 15-12-2022 15 4 Download
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Preclinical radiotherapy studies using mouse models are an indispensable step on the path from in vitro experiments to clinical implementation. In support of this step, dedicated small animal irradiators have been developed to provide a platform for testing new radiation strategies for cancer treatment.
8p vironald 15-12-2022 11 3 Download
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One of the newest developments within radiotherapy is the integration of Magnetic Resonance (MR) scanners and Megavoltage X-rays from linear accelerators into the new MR-Linacs. Some MR-Linacs are able to perform gated treatments based on continuously acquired 2D MR images taken during dose delivery, which has the potential to reduce margins required for tumor coverage.
11p vironald 15-12-2022 7 3 Download
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This paper reports the latest developments of the ACSpect and the results of the measurements of an accelerator-based neutron beam moderated by AlF3. The AlF3 is a moderator material optimised to obtain an epithermal neutron beam for accelerator-based BNCT of deep seated tumours.
8p vironald 15-12-2022 4 3 Download
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The hypothetical hydrostatic free surface is a new concept used to represent pressure distribution, calculate the pressure exerted on the wall of a moving closed tank with acceleration, translation or rotation around a fixed axis. The paper presents a common fluid mechanical problem, which has specific applications in liquid transport practice.
5p vimelindagates 18-07-2022 5 2 Download
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Lecture Survey and alignment in accelerators. The main topics covered in this chapter include: introduction to geodesy; steps of alignment; instrumentation toolkit; application to colliders: LHC, HL-LHC, CLIC and FCC; alignment R&D;...
170p charaznable 06-06-2022 10 2 Download
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The paper aims to detail the procedure of selecting and scaling recorded seismic accelerations according to requirements specified by TCVN-9386:2012. The target response spectrum and the fundamental vibration period of the considered structure are critical factors for the selecting and scaling process.
13p haoasakura 30-05-2022 8 1 Download
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In the context of rapid changes in the labor market and the need for international integration of labor, the paper focuses on analyzing the views of the Party and the State of Vietnam on establishing HSP labor relations. From this analysis, this paper proposes some recommendations for policymakers to build such labor relations in the period of accelerating industrialization, modernization, and international integration.
15p vithales 19-04-2022 9 1 Download
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Weaning is one of the most critical transition stages of the swine production cycle, as the piglet gut physiology and microbiome need to rapidly adapt to changes in diet and environmental conditions.
13p vigalileogalilei 28-02-2022 11 1 Download
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The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate “age acceleration” in various tissues and environments.
10p vielonmusk 30-01-2022 14 0 Download
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Epigenetic clocks are mathematical models that predict the biological age of an individual using DNA methylation data and have emerged in the last few years as the most accurate biomarkers of the aging process.
19p vielonmusk 30-01-2022 13 0 Download
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Chronic psychological stress is associated with accelerated aging and increased risk for aging-related diseases, but the underlying molecular mechanisms are unclear. Results: We examined the effect of lifetime stressors on a DNA methylation-based age predictor, epigenetic clock.
12p viaristotle 29-01-2022 10 0 Download
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Differentiation of lymphocytes is frequently accompanied by cell cycle changes, interplay that is of central importance for immunity but is still incompletely understood. Here, we interrogate and quantitatively model how proliferation is linked to differentiation in CD4+ T cells.
15p viaristotle 29-01-2022 9 0 Download
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Single-cell RNA-seq datasets are often first analyzed independently without harnessing model fits from previous studies, and are then contextualized with public data sets, requiring time-consuming data wrangling. We address these issues with sfaira, a single-cell data zoo for public data sets paired with a model zoo for executable pre-trained models.
21p viarchimedes 26-01-2022 6 0 Download
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LightGBM is an ensemble model of decision trees for classification and regression prediction. We demonstrate its utility in genomic selection-assisted breeding with a large dataset of inbred and hybrid maize lines.
24p viarchimedes 26-01-2022 6 0 Download
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