5-lipoxygenase mediates docosahexaenoyl ethanolamide and N-arachidonoyl-Lalanine-induced reactive oxygen species production and inhibition of proliferation of head and neck squamous cell carcinoma cells

Endocannabinoids have recently drawn attention as promising anti-cancer agents. We previously observed that anandamide (AEA), one of the representative endocannabinoids, effectively inhibited the proliferation of head and neck squamous cell carcinoma (HNSCC) cell lines in a receptor-independent manner.