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Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans
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The 2’-5’ oligoadenylate synthetase (OAS) locus encodes for three OAS enzymes (OAS1-3) involved in innate immune response. This region harbors high amounts of Neandertal ancestry in non-African populations; Yet, strong evidence of positive selection in the OAS region is still lacking.
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