Alcohol dehydrogenase, iron containing, 1 promoter hypermethylation associated with colorectal cancer differentiation

The aberrant methylation of CpG islands in the promoter is associated with colorectal cancer (CRC) carcinogenesis. In our previous study, the promoter of alcohol dehydrogenase, iron containing, 1 (ADHFE1) was most highly methylated in CRC compared to normal colorectal mucosa.