Anti-inflammatory activity of an anthraquinone derivative from Chamaecrista pumila (Lam.) K. Larsen in macrophages

Chamaecrista pumila has empirically been used to treat inflammation-associated complications. However, the molecular mechanism and chemical components underlying the anti-inflammatory activity of this medicinal plant are poorly understood. Hence, the present study aimed to identify main bioactive compounds from the ethyl acetate fraction of C. pumila extract, which was demonstrated to possess the strongest anti-inflammatory effect in a previous study, and provide mechanistic insights into modulation of inflammatory responses by the compound of interest.