Bài giảng Virus dại - PGS.TS. Cao Minh Nga

VIRUS DAÏI<br /> (RABIES VIRUS)<br /> <br /> PGS. TS. Cao Minh Nga<br /> BM. Vi sinh – Khoa Y – ÑHYD TP. HCM<br /> <br /> Noäi dung<br /> I. Tính chaát virus<br /> II. Sinh beänh hoïc<br /> III. Mieãn dòch<br /> IV. Trieäu chöùng<br /> V. Chaån ñoaùn virus hoïc<br /> VI. Dòch teã hoïc<br /> VII. Phoøng<br /> VIII. Ñieàu trò<br /> <br /> I. Tính chaát (rabies virus)<br /> - Gaây beänh daïi (rabies)<br /> - Laây truyeàn qua veát caén cuûa: + choù daïi (rabid dog)<br /> + ÑV coù vuù<br /> - Laø virus daïi coå ñieån, thöôøng gaây beänh cho ngöôøi,<br /> -  doøng Lyssavirus,  hoï Rhabdoviridae<br /> <br /> 1. Caáu truùc<br /> - Chöùa ARNss<br /> - MBN (+)<br /> <br /> - Capsid: ñoái xöùng xoaén oác<br /> - 2R  70 – 180 nm<br /> <br /> Sô ñoà caáu truùc virus daïi<br /> <br /> The lyssaviruses: structure and<br /> genetic organization<br /> .<br /> <br /> GENOME (negative polarity ) 12 kb<br /> <br /> Order: Mononegavirales<br /> Family: Rhadoviridae<br /> <br /> leader<br /> 3'<br /> <br /> N<br /> <br /> P<br /> <br /> M<br /> <br /> G<br /> <br /> L<br /> <br /> Trailer<br /> 5'<br /> <br /> TRANSCRIPTION<br /> <br /> PPP<br /> <br /> Prototype: rabies virus<br /> TRANSLATION<br /> Matrix protein Glycoprotein Polymérase<br /> <br /> Nucléoprotein PhosphoP<br /> <br /> REPLICATION<br /> <br /> Polymerase complexe<br /> <br /> (-) genomic RNA<br /> .<br /> <br /> (+) Antigenomic RNA<br /> <br /> MORPHOGENESIS<br /> <br /> 80 nm<br /> <br /> 200 nm<br /> LYSSAVIRUS REPLICATIVE CYCLE<br /> <br />