Báo cáo khoa học: cGMP-dependent protein kinase II and aldosterone secretion

Oligomeric assemblies of amyloid-b(Ab) are suggested to be central in the pathogenesis of Alzheimer’s disease because levels of soluble Abcorrelate much better with the extent of cognitive dysfunctions than do senile plaque counts. Moreover, such Abspecies have been shown to be neurotoxic, to interfere with learned behavior and to inhibit the maintenance of hippo-campal long-term potentiation.