Báo cáo khoa học: Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1a
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Hypoxia and inflammation often develop concurrently in numerous diseases, and both hypoxia-inducible factor (HIF)-1aand nuclear factor-kappaB (NF-jB) are key transcription factors of stress response genes. An NF-jB inhibitor, inhibitor of NF-jBa(IjBa), was found to interact with factor inhibiting HIF (FIH) and to be hydroxylated by FIH.
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