Báo cáo khoa học: Suppression of heat- and polyglutamine-induced cytotoxicity by nonsteroidal anti-inflammatory drugs
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We have shown that sodium salicylate activates the heat shock promoter and induces the expression of heat shock proteins (hsps), with a concomitant increase in the thermotolerance of cells. To determine whether these effects are generally displayed by nonsteroidal anti-inflammatory drugs (NSAIDs), we examined the effects of a cyclooxygenase inhibitor, indomethacin, and a lipoxyg-enase inhibitor, nordihydroguaiaretic acid. Both inhibitors up-regulated the hsp promoter at 37C through the acti-
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