Báo cáo khoa học: Targeted disruption of one of the importin a family members leads to female functional incompetence in delivery
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Importinamediates the nuclear import of proteins through nuclear pore complexes in eukaryotic cells, and is common to all eukaryotes. Previous reports identified at least six importinafamily genes in mice. Although these isoforms show differential binding to various import cargoes in vitro, the in vivo physiological roles of these mammalian importina isoforms remain unknown.
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