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Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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The cytotoxic action of some ribonucleases homologous to bovine pancre-atic RNase A, the superfamily prototype, has interested and intrigued investigators. Their ribonucleolytic activity is essential for their cytotoxic action, and their target RNA is in the cytosol. It has been proposed that the cytosolic RNase inhibitor (cRI) plays a major role in determining the ability of an RNase to be cytotoxic.

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Nội dung Text: Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases

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