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Báo cáo sinh học: " Bacteriophages: The viruses for all seasons of molecular biology"

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Virology Journal BioMed Central Open Access Commentary Bacteriophages: The viruses for all seasons of molecular biology Jim D Karam* Address: Department of Biochemistry, Tulane University Health Sciences Center, New Orleans, Louisiana USA Email: Jim D Karam* - karam@tulane.edu * Corresponding author Published: 15 March 2005 Received: 13 December 2004 Accepted: 15 March 2005 Virology Journal 2005, 2:19 doi:10.1186/1743-422X-2-19 This article is available from: http://www.virologyj.com/content/2/1/19 © 2005 Karam; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Bacteriophage research continues to break new ground in our understanding of the basic molecular mechanisms of gene action and biological structure. The abundance of bacteriophages in nature and the diversity of their genomes are two reasons why phage research brims with excitement. The pages of Virology Journal will reflect the excitement of the "New Phage Biology." The launching of Virology Journal comes at a time of resur- where bacteria or archaea reside [4]. At one level, there is gence of interest in the basic biology of the bacteriophages diversity in the types of phages that infect individual or and the impact that these viruses have on earth's ecology, interrelated bacterial species. At another level, there is evolution of microbial diversity and the control of infec- diversity among genomically related phages that do not tious disease. Since playing an important part in the birth share the same bacterial hosts. One example is the lytic of Molecular Biology more than 50 years ago [1], phage Enterobacterial dsDNA phage T4, which has relatives that research has continually broken new ground in our under- are specific to Aeromonas, Vibrio, Acinetobacter, marine and standing of the basic molecular mechanisms of gene other bacterial species. The genomes of a few T4-like action and biological structure [2]. This trend shows no phages have been sequenced and found to indeed share signs of waning. In a recent international meeting entitled homologies with T4, but to also differ from one another The New Phage Biology [3], the program was largely in size, organization of the T4-like genes and content of devoted to emerging frontiers of research that have been other putative genes and DNA mobile elements (http:// empowered by a rapid accumulation of genome sequence phage.bioc.tulane.edu). It appears that phage families like information from a wide variety of bacteriophages. Phage the T4-related phages have learned to cross bacterial spe- genomics is revealing novel biochemical mechanisms for cies barriers and possess plastic genomes that can acquire replication, maintenance and expression of the genetic and lose genetic cassettes through their travels in the material and is providing new insights into origins of microbial world. In essence, genomes of the dsDNA infectious disease and the potential use of phage gene phages may be repositories of the genetic diversity of all products and even whole phage as therapeutic agents. microorganisms in nature. Two reasons why the new era of phage research brims In addition to evolving by serving as traffickers of micro- with excitement are the abundance of bacteriophages in bial genes, phage genomes evolve through the accumula- nature and the diversity of their genomes. Phage is proba- tion of mutations in both acquired and core genes. bly the most widely distributed biological entity in the Sequence divergence among homologues of the essential biosphere, with an estimated population of >1030 or ~10 genes for phage propagation within a phage family can be million per cubic centimeter of any environmental niche used as a source of information about the determinants of Page 1 of 2 (page number not for citation purposes)
Virology Journal 2005, 2:19 http://www.virologyj.com/content/2/1/19 specificity of the protein-protein and protein-nucleic-acid interactions that underlie biological function. Phages are excellent sources of many enzymes and biochemical transactions that are broadly represented in all divisions of life. The large numbers of phylogenetic variants of bio- logically interesting proteins and nucleic acids that one can derive from sequenced phage genomes are treasure troves for studies of biological structure in relation to function. Interest in phage and phage gene products as potential therapeutic agents is also increasing rapidly and is likely to have profound impact on the pharmaceutical industry and biotechnology in general over the coming years. There is a general sense that the best is yet to come out of phage research. Conclusion We anticipate that the pages of Virology Journal will reflect the excitement of the "New Phage Biology" by publishing reports in the areas of Ecology and Taxonomy, Genomics and Molecular Evolution, Regulation of Gene Expression, Genome Replication and Maintenance, Protein and Nucleic Acid Structure, Virus assembly, Biotechnology, Pathogenesis, Therapeutics and more. It would be espe- cially interesting to see submissions of phage genome sequence briefs and their biological implications. Competing interests The author(s) declare that they have no competing inter- ests. References 1. Cairns J, Stent GS, Watson JD: Phage and the Origins of Molec- ular Biology", Expanded Edition. New York, Cold Spring Harbor Laboratory Press; 1992. 2. Calendar R: The Bacteriophages. Oxford: Oxford University Press in press. 3. Adhya S, Young R: The New Phage Biology: ; Key Biscayne, FL. ; 2004. 4. Wommack KE, Colwell RR: Virioplankton: viruses in aquatic ecosystems. Microbiol Mol Biol Rev 2000, 64:69-114. Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical researc h in our lifetime." Sir Paul Nurse, Cancer Research UK Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright BioMedcentral Submit your manuscript here: http://www.biomedcentral.com/info/publishing_adv.asp Page 2 of 2 (page number not for citation purposes)

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