Breast ductal lavage for biomarker assessment in high risk women: Rationale, design and methodology of a randomized phase II clinical trial with nimesulide, simvastatin and placebo

Despite positive results from large phase III clinical trials proved that it is possible to prevent estrogen-responsive breast cancers with selective estrogen receptor modulators and aromatase inhibitors, no significant results have been reached so far to prevent hormone non-responsive tumors.