Combining solid lipid-nanoparticles in Alginate coating formulation to prepare enteric-released Diclofenac pellets

In the trend of using natural-resource substances in current pharmaceutical industry, alginate (ALG) film was used to coat tablets. To further develop ALG film-coating, solid lipid nanoparticles of cetearyl alcohol (ACS) or glycerol monostearate (GMS) were added in the coating formulation, applying to the diclofenac sodium (Na-D) pellet.