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Context dependent regulatory patterns of the androgen receptor and androgen receptor target genes
Chia sẻ: ViNaypyidaw2711 ViNaypyidaw2711 | Ngày: | Loại File: PDF | Số trang:15
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Expression of the androgen receptor (AR) is associated with androgen-dependent proliferation arrest and terminal differentiation of normal prostate epithelial cells. Additionally, activation of the AR is required for survival of benign luminal epithelial cells and primary cancer cells, thus androgen deprivation therapy (ADT) leads to apoptosis in both benign and cancerous tissue.
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