Efficacy of palonosetron–dexamethasone combination versus palonosetron alone for preventing nausea and vomiting related to opioid based analgesia: A prospective, randomized, double-blind trial

The efficacy of dexamethasone plus palonosetron for postoperative nausea and vomiting (PONV) prophylaxis is not firmly established. This randomized, double-blind, controlled study evaluated whether the combination was superior to palonosetron alone in preventing PONV in patients receiving intravenous patient-controlled analgesia (IV-PCA) after upper extremity surgery.