Emergence of spatio-temporal variations in chemotherapeutic drug efficacy: In-vitro and in-Silico 3D tumour spheroid studies

The mechanisms of action and efficacy of cisplatin and paclitaxel at cell population level are well studied and documented, however the localized spatio-temporal effects of the drugs are less well understood. We explore the emergence of spatially preferential drug efficacy resulting from variations in mechanisms of cell-drug interactions.