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GRiNCH: Simultaneous smoothing and detection of topological units of genome organization from sparse chromatin contact count matrices with matrix factorization
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High-throughput chromosome conformation capture assays, such as Hi-C, have shown that the genome is organized into organizational units such as topologically associating domains (TADs), which can impact gene regulatory processes. The sparsity of Hi-C matrices poses a challenge for reliable detection of these units.
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