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Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis
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Upregulation of the mitogen-activated protein kinase (MAPK) cascade is common in hepatocellular carcinoma (HCC). Neuroblastoma RAS viral oncogene homolog (NRAS) is mutated in a small percentage of HCC and is hitherto considered insufficient for hepatocarcinogenesis.
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