Impact of a one-year supervised physical activity program on long-term cancerrelated fatigue and mediating effects of the gut microbiota in metastatic testicular cancer patients: Protocol of the prospective multicentre, randomized controlled phase-III STARTER trial

Testicular germ cell tumours (TGCTs) are the most common malignancy in men aged 15–40 years, with increasing incidence worldwide. About 33~50% of the patients present with metastatic disease at diagnosis. TGCT survivors experience short- and long-term sequelae, including cancer-related fatigue (CRF).