MiR-449a suppresses the epithelialmesenchymal transition and metastasis of hepatocellular carcinoma by multiple targets

Increasing evidence indicates that Epithelial–mesenchymal transition (EMT) can be regulated by microRNAs (miRNAs). MiR-449a is a liver abundant miRNA. However, the role of miR-449a in the metastasis of hepatocellular carcinoma (HCC) remains largely unknown.