Modelling the simultaneous chiral separation of a group of drugs by electrokinetic chromatography using mixtures of cyclodextrins

Two mixtures of neutral cyclodextrins (CDs) were used in Electrokinetic Chromatography (EKC) to model and optimize the simultaneous enantiomeric separation of a group of seven drugs. Heptakis(2,6-di-Omethyl)-β-CD (DM-β-CD) combined with methyl-γ -CD (M-γ -CD) or with carboxyethyl-γ -CD (CE-γ -CD) was employed in a 25 mM formate buffer at pH 3.0 to have the drugs studied positively charged.