Nanocurcumin and chitosan-pluronic F127-based hydrogel for 3rd degree burn treatment

In the study, we fabricated a thermosensitive nanocomposite hydrogel, which incorporated dual active curcumin and chitosan. Beside of a well-known characteristic of chitosan for wound healing, curcumin has been a lot of interest in burn wound healing application due to ability in depleting the action of oxidative radicals and stimulation of fibroblast cells. In order to enhance the therapeutic efficacy of curcumin, we introduced a new method to synthesize nanocurcumin in the thermosensitive chitosan-g-Pluronic F127 copolymer solution under ultrasonication.