The rheumatoid arthritis shared epitope increases cellular susceptibility to oxidative stress by antagonizing an adenosine-mediated anti-oxidative pathway

The rheumatoid arthritis shared epitope increases cellular susceptibility to oxidative stress by antagonizing an adenosine-mediated anti-oxidative pathway Song Ling1, Zhanguo Li1,2, Olga Borschukova3, Liqun Xiao1, Paul Pumpens3 and Joseph Holoshitz1 1Department 2Department of Internal Medicine, University of Michigan, 1150 W. Medical Center Dr., 5520 MSRB I, Ann Arbor, MI 48109-0680, USA of Rheumatology, Beijing Medical University, Beijing, 11 S. Xizhimen Blvd, Beijing, 100044, The People's Republic of China 3Biomedical Research and Study Center, University of Latvia, Ratsupites 1, Riga, LV-1067, Latvia Corresponding author: Joseph Holoshitz, jholo@umich.edu Received: 19 Oct 2006 Revisions requested: 24 Nov 2006 Revisions received: 17 Dec 2006 Accepted: 25 Jan...