Acetylcholinesterase inhibitors

Acetylcholinesterase (AChE) has been one of the important and potential targets in the discovery, and development of new drugs for treating and slowing the progression of Alzheimer's disease (AD). This research suggests potential structural frameworks for synthesizing AChE inhibitor derivatives for treating AD.

11p vihyuga 04-03-2025 1 1   Download

Acetylcholinesterase (AChE) is a key therapeutic target for developing new Alzheimer's disease (AD) treatments due to its regulatory function in acetylcholine hydrolysis. This research contributed to the development of a novel scaffold for AChE inhibitors, which are potential drugs for treating AD.

17p vihyuga 04-03-2025 5 1   Download

The selective effects of these inhibitors are governed by substituent at position 5. Kinetic studies and molecular docking simulation were performed for elucidating mechanisms of enzyme-inhibitor complex formation.

12p tocectocec 25-05-2020 10 1   Download

Our recent studies have shown that, as indicated by vagal stimulation, an acetylcholinesterase inhibitor donepezil, an anti-Alzheimer’s disease drug, prevents progression of heart failure in rats with myocardial infarction, and activates a common cell survival signal shared by acetylcholine (ACh) in vitro.

15p vinaphone15 25-02-2013 36 3   Download

The hydrolysis of acetylthiocholine by acetylcholinesterase fromElectro-phorus electricuswas investigated in the presence of the inhibitors tacrine, gallamine and compound1. The interaction of the enzyme with the sub-strate and the inhibitors was characterized by the parametersKI , a¢, borb, Kmand Vmax, which were determined directly and simultaneously from nonlinear Michaelis–Menten plots.

16p viettel02 22-02-2013 25 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies

13p toshiba23 18-11-2011 84 3   Download